Dr. Talley is a consultant, researcher, and Chief Scientific Officer. After his years of research in Toxicology, Crystallography and Neuropharmacology, Dr. Talley consults and oversees scientific operations for several private companies throughout Washington state. Have a business in need of analytic-driven strategies? Reach out for a consultation by emailing: tttalley@live.com.
University of California, San Diego, La Jolla, CA, US
University of Montana, Missoula, MT, US Ph.D. in Organic/Medicinal Chemistry Thesis advisor: Professor Charles M. Thompson, 2001
University of Utah, Salt Lake City, UT, US
B.S. in Chemistry (Professional Interdisciplinary), 1995
National Institutes of Health National Research Service Award; accepted May 2002
Tobacco-Related Disease Research Program Postdoctoral Fellowship; declined June 2002
National Institutes of Health National Research Service Award; declined July 2002
Assistant Professor Department of Biomedical and Pharmaceutical Sciences, Idaho State University College of Pharmacy Meridian, ID 83642-7991 2012-2017
Adjunct Professor Department of Physical and Natural Sciences, College of Western Idaho Nampa, ID 83687 2012-2017
Project Scientist Skaggs School of Pharmacy and Pharmaceutical Sciences, University of California, San Diego La Jolla, CA 92093-0636 2007-2012
Post-graduate Researcher Department of Pharmacology, University of California, San Diego La Jolla, CA 92093-0636 2005-2006
Post-doctoral Fellow Department of Pharmacology, University of California, San Diego La Jolla, CA 92093-0636 2001-2005
American Society for Pharmacology and Experimental Therapeutics
American Association of Colleges of Pharmacy
American Association for Cancer Research
American Crystallographic Association
James Hunt
Jennifer Amerhmze
Martina Wilson
Kayla Gallegos
Jesse Coward
Diana Nguyen
Lois Godinez
Erin Lowder
Cassie Gaige
John Park
Joshua Wu
Phuong Thoi
Cuong Dao
Nan Aye
Christopher P.H. Redgate
Janet Bobango (ASPET travel award 2016 & AFPE Scholar 2016/2017)
Nicole Frank (2016)
Lee Schroeder (Ph.D. 2009 MD 2011)
Akos Nemecz (2011)
Megan Miller (2010)
Ann Valle (2009)
Drugs from worms and snails – oh my!
College of Western Idaho Visiting Scientist Lecture, Nampa, Idaho, September 2015
Exploring the molecular determinants of specificity.
Washington State University, College of Pharmacy, Spokane, Washington, September 2015
Specificity – can it be achieved?
Annual Meeting of the American Crystallographic Association, Philadelphia, Pennsylvania, July 2015
Structural information for building better drugs.
Idaho Academy of Science, Boise State University, Boise, Idaho, March 2015
Fun with the Acetylcholine binding proteins.
Washington State University, Department of Chemistry, Pullman, Washington, October 2014
Understanding the structural basis of ligand interactions with nicotinic acetylcholine receptors through x-ray crystallographic and molecular recognition analysis.
University of New England, College of Pharmacy, Portland, Maine, August 2014
Searching for specificity: The acetylcholine binding protein as a tool for drug discovery.
Translating chemistry into medicines symposium at the 69th Northwest Regional Meeting of the American Chemical Society, Missoula, Montana, June 2014
A quest for specificity: The acetylcholine binding protein as a tool for drug discovery.
Ligands: a BCSB nano-workshop, Berkeley, California, May 2014
Drugs from worms and snails – oh my! The acetylcholine binding proteins as tools for drug discovery.
Bimolecular Sciences Graduate Seminar Series at Boise State University, Boise, Idaho, March 2014
A Case Study; Working with Souflikar for Automated Data Processing of 13 Structures in 1 day.
Advanced Light Source User Meeting, Berkeley, California, October 2012
Acetylcholine Binding Protein-Nicotinic Receptor Chimeras for Delineating Structure and Determinants of Ligand Selectivity.
67th Northwest Regional Meeting of the American Chemical Society, Boise, Idaho, June 2012
Acetylcholine Binding Protein-Nicotinic Receptor Chimeras for Delineating Structure and Determinants of Ligand Selectivity.
Nicotinic Acetylcholine Receptors as Therapeutic Targets, Washington, D.C., November 2011
Protein structure and function: An introduction to visualization software and web based resources for protein exploration.
Tijuana, Mexico, October 13th, 2009
Dissecting the molecular determinants of ligand recognition and binding for nicotinic receptors; Lessons from crystallographic and solution based studies of the acetylcholine binding proteins.
La Seerena, Chile, October 12th, 2008
Nicotinic Receptors: Structure, function and drug design.
Tijuana, Mexico, September 4th, 2008
Drugs from worms and snails: The acetylcholine binding protein as a tool in drug design.
Bangkok, Thailand, March 20th, 2008
Frank NE, Cusack BJ, Talley TT, Walsh GM, & Olson RD (2016) Comparative Effects of Doxorubicin and a Doxorubicin Analog, 13-deoxy, 5-iminodoxorubicin (GPX-150), on Human Topoisomerase IIβ Activity and Cardiac Function in a Chronic Rabbit Model. Investigational New Drugs, 34, 693-701.
Rodríguez LP, Vilariño N, Molgó J, Araoz R, Louzao MC, Taylor P, Talley TT, & Botana LM (2013) Development of a Solid-Phase Receptor-Based Assay for the Detection of Cyclic Imines Using a Microsphere-Flow Cytometry System. Anal Chem, 85 (4), 2340-7
Yamauchi JG, Gomez K, Grimster N, Dufouil M, Nemecz A, Fotsing JR, Ho KY, Talley TT, Sharpless KB, Fokin VV, & Taylor P (2012) Synthesizing Selective Agonists for the alpha7 Nicotinic Receptor with in situ Click-Chemistry on Acetylcholine Binding Protein Templates. Mol Pharmacol 82(4):687-699.
Rojsanga P, Boonyarat C, Utsintong M, Nemecz A, Yamauchi JG, Talley TT, Olson AJ, Matsumoto K, & Vajragupta O (2012) The effect of crebanine on memory and cognition impairment via the alpha-7 nicotinic acetylcholine receptor. Life Sci 91(3-4):107-114.
impairment via the alpha-7 nicotinic acetylcholine receptor. Life Sci 91(3-4):107-114. Grimster NP, Stump B, Fotsing JR, Weide T, Talley TT, Yamauchi JG, Nemecz A, Kim C, Ho KY, Sharpless KB, Taylor P, Fokin VV (2012) Generation of Candidate Ligands for Nicotinic Acetylcholine Receptors via in situ Click Chemistry with a Soluble Acetylcholine Binding Protein Template. J Am Chem Soc 134(15):6732-6740.
Utsintong M, Rojsanga P, Ho KY, Talley TT, Olson AJ, Matsumoto K, Vajragupta O (2012) Virtual Screening against Acetylcholine Binding Protein. J Biomol Screen 17(2):204-215.
Yamauchi JG, Nemecz A, Nguyen QT, Muller A, Schroeder LF, Talley TT, Lindstrom J, Kleinfeld D, Taylor P (2011) Characterizing ligand-gated ion channel receptors with genetically encoded Ca2++ sensors. PLoS One 6: e16519.
Kombo DC, Mazurov A, Tallapragada K, Hammond PS, Chewning J, Hauser TA, Vasquez-Valdivieso M, Yohannes D, Talley TT, Taylor P, and Caldwell WS (2011) Docking studies of benzylidene anabaseine interactions with alpha7 nicotinic acetylcholine receptor (nAChR) and acetylcholine binding proteins (AChBPs): Application to the design of related alpha7 selective ligands. Eur J Med Chem 46(11):5625-5635.
Bourne Y, Radic Z, Araoz R, Talley TT, Benoit E, Servent D, Taylor P, Molgo J, & Marchot P (2010) Structural determinants in phycotoxins and AChBP conferring high affinity binding and nicotinic AChR antagonism. Proc Natl Acad Sci U S A 107(13):6076-6081.
Utsintong M, Talley TT, Taylor PW, Olson AJ, & Vajragupta O (2009) Virtual screening against alpha-cobratoxin. J Biomol Screen 14(9):1109-1118.
Tomizawa M, Talley TT, Park JF, Maltby D, Medzihradszky KF, Durkin KA, Cornejo-Bravo JM, Burlingame AL, Casida JE, & Taylor P (2009) Nicotinic agonist binding site mapped by methionine- and tyrosine-scanning coupled with azidochloropyridinyl photoaffinity labeling. J Med Chem 52(12):3735-3741.
Rana BK, Wessel J, Mahboubi V, Rao F, Haeller J, Gayen JR, Eskin E, Valle AM, Das M, Mahata SK, Taupenot L, Stridsberg M, Talley TT, Ziegler MG, Smith DW, Schork NJ, O'Connor DT, & Taylor P (2009) Natural variation within the neuronal nicotinic acetylcholine receptor cluster on human chromosome 15q24: influence on heritable autonomic traits in twin pairs. J Pharmacol Exp Ther 331(2):419-428.
Hibbs RE, Sulzenbacher G, Shi J, Talley TT, Conrod S, Kem WR, Taylor P, Marchot P, & Bourne Y (2009) Structural determinants for interaction of partial agonists with acetylcholine binding protein and neuronal alpha7 nicotinic acetylcholine receptor. Embo J 28(19):3040-3051.
Babakhani A, Talley TT, Taylor P, & McCammon JA (2009) A virtual screening study of the acetylcholine binding protein using a relaxed-complex approach. Comput Biol Chem 33(2):160-170.
Tomizawa M, Maltby D, Talley TT, Durkin KA, Medzihradszky KF, Burlingame AL, Taylor P, & Casida JE (2008) Atypical nicotinic agonist bound conformations conferring subtype selectivity. Proc Natl Acad Sci U S A 105(5):1728-1732
Talley TT, Harel M, Hibbs RE, Radic Z, Tomizawa M, Casida JE, & Taylor P (2008) Atomic interactions of neonicotinoid agonists with AChBP: molecular recognition of the distinctive electronegative pharmacophore. Proc Natl Acad Sci U S A 105(21):7606-7611.
Tomizawa M, Talley TT, Maltby D, Durkin KA, Medzihradszky KF, Burlingame AL, Taylor P, & Casida JE (2007) Mapping the elusive neonicotinoid binding site. Proc Natl Acad Sci U S A 104(21):9075-9080
Tomizawa M, Maltby D, Medzihradszky KF, Zhang N, Durkin KA, Presley J, Talley TT, Taylor P, Burlingame AL, & Casida JE (2007) Defining nicotinic agonist binding surfaces through photoaffinity labeling. Biochemistry 46(30):8798-8806.
Taylor P, Talley TT, Radic Z, Hansen SB, Hibbs RE, & Shi J (2007) Structure-guided drug design: conferring selectivity among neuronal nicotinic receptor and acetylcholine-binding protein subtypes. Biochem Pharmacol 74(8):1164-1171
Kang TS, Radic Z, Talley TT, Jois SD, Taylor P, & Kini RM (2007) Protein folding determinants: structural features determining alternative disulfide pairing in alpha- and chi/lambda-conotoxins. Biochemistry 46(11):3338-3355.
Talley TT, Yalda S, Ho KY, Tor Y, Soti FS, Kem WR, & Taylor P (2006) Spectroscopic analysis of benzylidene anabaseine complexes with acetylcholine binding proteins as models for ligand-nicotinic receptor interactions. Biochemistry 45(29):8894-8902.
Talley TT, Olivera BM, Han KH, Christensen SB, Dowell C, Tsigelny I, Ho KY, Taylor P, & McIntosh JM (2006) Alpha-conotoxin OmIA is a potent ligand for the acetylcholine-binding protein as well as alpha3beta2 and alpha7 nicotinic acetylcholine receptors. J Biol Chem 281(34):24678-24686.
Bourne Y, Hansen SB, Sulzenbacher G, Talley TT, Huxford T, Taylor P, & Marchot P (2006) Structural comparison of three crystalline complexes of a peptidic toxin with a synaptic acetylcholine recognition protein. J Mol Neurosci 30(1-2):103-104.
Bourne Y, Talley TT, Hansen SB, Taylor P, & Marchot P (2005) Crystal structure of a Cbtx-AChBP complex reveals essential interactions between snake alpha-neurotoxins and nicotinic receptors. Embo J 24(8):1512-1522.
Taylor P, Hansen SB, Talley TT, Hibbs RE, & Radic Z (2004) Contemporary paradigms for cholinergic ligand design guided by biological structure. Bioorg Med Chem Lett 14(8):1875-1877.
Hibbs RE, Talley TT, & Taylor P (2004) Acrylodan-conjugated cysteine side chains reveal conformational state and ligand site locations of the acetylcholine-binding protein. J Biol Chem 279(27):28483-28491.
Hansen SB, Talley TT, Radic Z, & Taylor P (2004) Structural and ligand recognition characteristics of an acetylcholine-binding protein from Aplysia californica. J Biol Chem 279(23):24197-24202.
Gao F, Bern N, Little A, Wang HL, Hansen SB, Talley TT, Taylor P, & Sine SM (2003) Curariform antagonists bind in different orientations to acetylcholine-binding protein. J Biol Chem 278(25):23020-23026.
Hansen SB, Radic Z, Talley TT, Molles BE, Deerinck T, Tsigelny I, & Taylor P (2002) Tryptophan fluorescence reveals conformational changes in the acetylcholine binding protein. J Biol Chem 277(44):41299-41302.
Doorn JA, Talley TT, Thompson CM, & Richardson RJ (2001) Probing the active sites of butyrylcholinesterase and cholesterol esterase with isomalathion: conserved stereoselective inactivation of serine hydrolases structurally related to acetylcholinesterase. Chem Res Toxicol 14(7):807-813.
Doorn JA, Schall M, Gage DA, Talley TT, Thompson CM, & Richardson RJ (2001) Identification of butyrylcholinesterase adducts after inhibition with isomalathion using mass spectrometry: difference in mechanism between (1R)- and (1S)-stereoisomers. Toxicol Appl Pharmacol 176(2):73-80.
Doorn JA, Gage DA, Schall M, Talley TT, Thompson CM, & Richardson RJ (2000) Inhibition of acetylcholinesterase by (1S,3S)-isomalathion proceeds with loss of thiomethyl: kinetic and mass spectral evidence for an unexpected primary leaving group. Chem Res Toxicol 13(12):1313-1320.
Jianmongkol S, Marable BR, Berkman CE, Talley TT, Thompson CM, & Richardson RJ (1999) Kinetic evidence for different mechanisms of acetylcholinesterase inhibition by (1R)- and (1S)-stereoisomers of isomalathion. Toxicol Appl Pharmacol 155(1):43-53.
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